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Standard Guide for Assessing the Skeletal Myoblast Phenotype Ingestion-build-100580 What is BS EN 3774-0041. Scope 1. 1 Myogenic differentiation is a process regulated by specific transcription factors and signaling molecules that have been shown to induce a myogenic phenotype. Transcription factors mark the stages of myogenesis and act as benchmarks for use in myogenic assays.